Generic Name  : Ceftazidime.

Trade Name      : Fortum.

Drug Class       : Third Generation Cephalosporins.

Forms of The Drug

  1. Injection: IV or IM 250mg, 500mg, 1g.
  2. Powder for Reconstitution.
  3. Inhalation Solution.

Mechanism of Action

Binding to 1 or more penicillin-binding proteins, thereby, in turn, inhibiting final transpeptidation step of peptidoglycan synthesis in bacterial cell-wall synthesis and inhibiting cell-wall biosynthesis and thus arresting bacterial growth.

Indications

  1. Lower respiratory tract infections.
  2. Skin and skin structure infections.
  3. Urinary tract infections.
  4. Bacterial septicemia.
  5. Bone and joint infections.
  6. Gynecologic infections.
  7. Intra-abdominal infections (including peritonitis).
  8. Central nervous system infections.

Contraindications

  1. Hypersensitivity to drug or excipients.
  2. Diarrhea from an infection with Clostridium difficile bacteria.
  3. inflammation of the large intestine.
  4. Chronic kidney disease.
  5. Liver problems.
  6. Decrease in the blood clotting protein prothrombin.

Side Effects

  1. Transient increases in transaminases (3-9%).
  2. Eosinophilia (<7%).
  3. Diarrhea (<2%).
  4. Immune hypersensitivity reaction (2%).
  5. Phlebitis (<2%).
  6. Rash (maculopapular or erythematous) (2%).
  7. Thrombocytosis (2%).
  8. Injection site pain (1%).

Drug Interaction

Interaction occurs when it is given with certain drugs.

  1. Probenecid.
  2. Aminoglycoside antibiotics such as gentamicin, tobramycin, or amikacin.
  3. Diuretics, particularly furosemide.
  4. Anticoagulants such as warfarin.
  5. Other antibiotics such as clindamycin or erythromycin.

Precautions

  1. Pregnancy: Category B.
  2. Lactation: Drug enters breast milk, may be used with cauation.

Leave a Reply

Your email address will not be published. Required fields are marked *