Generic Name: Heptaminol.

Trade Name    : Corasore.

Drug Class      : Vasodilators.

Forms of The Drug

  1. Tablets or Capsules.
  2. Oral Solution.
  3. Injectable Solution.
  4. Topical Preparations.
  5. Combination Formulations.

Mechanism of Action

The mechanism of action of heptaminol is not fully understood, but it is believed to exert its effects through several mechanisms:

  1. Beta-Adrenergic Stimulation: Heptaminol has been shown to have a mild beta-adrenergic stimulating effect. This means it can activate beta-adrenergic receptors, which are typically activated by substances like adrenaline (epinephrine). When these receptors are activated, they can lead to increased heart rate (positive chronotropic effect) and increased force of contraction (positive inotropic effect), ultimately enhancing cardiac output.
  2. Vasodilation: One of the main effects of heptaminol is its vasodilatory action. It relaxes and widens the blood vessels, particularly the arterioles. This vasodilation reduces peripheral vascular resistance, which in turn can lead to a decrease in blood pressure. By promoting better blood flow through the vessels, heptaminol can alleviate conditions like peripheral vascular diseases and circulatory disorders.
  3. Increased Blood Flow: By relaxing blood vessels and reducing vascular resistance, heptaminol can enhance blood flow to various tissues and organs. Improved blood circulation is crucial for delivering oxygen and nutrients to cells and removing waste products efficiently.
  4. Positive Inotropic Effect: Heptaminol’s mild positive inotropic effect on the heart means it enhances the contractility of the heart muscle. This can be beneficial in cases of heart failure or other conditions where the heart’s pumping ability is compromised.
  5. Enhanced Coronary Blood Flow: The vasodilatory properties of heptaminol can extend to the coronary arteries that supply blood to the heart muscle itself. By dilating these arteries, heptaminol may increase coronary blood flow, providing the heart with more oxygen and nutrients.

Indications

  1. Peripheral Vascular Diseases.
  2. Intermittent Claudication.
  3. Raynaud’s Phenomenon.
  4. Enhancement of Blood Circulation.
  5. Adjunctive Treatment for Heart Failure.
  6. Post-Surgical Recovery.
  7. Adjunctive Treatment for Shock.

Contraindications

  1. Hypersensitivity to Heptaminol.
  2. Severe Hypotension.
  3. Acute Myocardial Infarction (Heart Attack).
  4. Cardiogenic Shock.
  5. Aortic Stenosis.
  6. Pulmonary Hypertension.
  7. Coronary Artery Disease.
  8. Pregnancy and Breastfeeding.
  9. Children and Pediatric Use.

Side Effects

  1. Bradycardia (10%).
  2. Hypertension or increased blood pressure (8.9%).
  3. Atrial fibrillation (8.3%).
  4. Luminous phenomena (phosphenes) or visual brightness (2.8%).
  5. Syncope, hypotension.
  6. Angioedema, erythema, rash, pruritus, urticaria.
  7. Vertigo, diplopia, visual impairment.
  8. Torsade de pointes, ventricular fibrillation, ventricular tachycardia.

Drug Interaction

Other drugs that can interact with it.

  1. Hypotensive Agents.
  2. Beta-Blockers.
  3. Nitrates.
  4. Sympathomimetics.
  5. Alpha-Blockers.
  6. Diabetes Medications.
  7. Anticoagulants and Antiplatelet Drugs: Heptaminol’s effects on blood flow could potentially interact with anticoagulants (blood thinners) and antiplatelet drugs.
  8. Central nervous system depressants such as sedatives, tranquilizers, or alcohol.
  9. Monoamine Oxidase Inhibitors (MAOIs).
  10. Other Cardiovascular Medications.

Precautions

  1. Pregnancy: There are no adequate and well-controlled studies in pregnant women to inform any drug-associated risks. May cause fetal toxicity when administered to a pregnant woman, based on findings in animal studies.
  2. Lactation: When it comes to the effects of medications on lactation, it’s important to exercise caution and consult with a healthcare professional. Medications can potentially pass into breast milk, and their impact on both the nursing infant and lactating individual needs to be evaluated.

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