Generic Name: Nebivolol.

Trade Name   : Nebilet.

Drug Class     : Selective Beta- Adrenoceptor antagonist.

Forms of The Drug

  • Tablet: 2.5mg, 5mg, 10mg, 20mg.

Mechanism of Action

Nebivolol is a medication classified as a beta-blocker, and it is primarily used to treat conditions such as hypertension (high blood pressure) and certain cardiac disorders. Its mechanism of action is related to its ability to block beta-adrenergic receptors, specifically the beta-1 (β1) receptors, found primarily in the heart. Here’s a breakdown of how Nebivolol works:

  1. Selective Beta-1 Receptor Blockade: Nebivolol is considered a selective beta-1 adrenergic receptor antagonist. This means it has a higher affinity for beta-1 receptors, which are predominantly located in the cardiac muscle cells (myocytes) of the heart.
  2. Heart Rate Reduction: By blocking beta-1 receptors in the heart, Nebivolol reduces the effects of adrenaline (epinephrine) and norepinephrine, which are stress hormones that stimulate the heart to beat faster. These hormones typically bind to beta-1 receptors, leading to an increase in heart rate (positive chronotropic effect). Nebivolol, by inhibiting this action, decreases the heart rate (negative chronotropic effect).
  3. Reduction in Contractility: Nebivolol also reduces the force of contraction of the heart muscle (negative inotropic effect). This effect results in decreased cardiac output and a reduction in the heart’s workload. This reduction in contractility helps the heart pump blood more efficiently and with less oxygen consumption.
  4. Vasodilation: Unlike some other beta-blockers, Nebivolol has an additional unique mechanism of action. It stimulates the release of nitric oxide (NO) from the endothelial cells that line blood vessels. Nitric oxide is a potent vasodilator, which relaxes and widens blood vessels. This vasodilatory effect leads to reduced peripheral vascular resistance, making it easier for the heart to pump blood against less resistance, thereby lowering blood pressure.
  5. Anti-Arrhythmic Effects: Nebivolol can help stabilize heart rhythm by preventing or reducing the occurrence of certain arrhythmias, particularly ventricular arrhythmias and atrial fibrillation.
  6. Endothelial Function Improvement: Nebivolol’s ability to increase nitric oxide levels may also improve endothelial function, which is essential for overall cardiovascular health. A well-functioning endothelium helps regulate blood vessel tone, inflammation, and clotting.

Indications

  1. Hypertension (High Blood Pressure).
  2. Chronic heart failure.
  3. Reducing Cardiovascular Risk.
  4. Post-myocardial infarction (Heart Attack) management.
  5. Arrhythmias.
  6. Angina pectoris.
  7. Diastolic dysfunction.
  8. Vascular health improvement.

Contraindications

  1. Hypersensitivity.
  2. Bradycardia (Slow Heart Rate).
  3. Heart block.
  4. Cardiogenic shock.
  5. Severe hypotension (Low Blood Pressure).
  6. Severe Peripheral Arterial Disease (PAD).
  7. Pheochromocytoma without adequate alpha-blockade.
  8. Asthma or Chronic Obstructive Pulmonary Disease (COPD).
  9. Allergic rhinitis.
  10. Metabolic acidosis.
  11. Pregnancy and breastfeeding.

Side Effects

  1. Headache (6-9%).
  2. Fatigue (2-5%).
  3. Dizziness (2-4%).
  4. Diarrhea (2-3%).
  5. Nausea (1-3%).
  6. Increased triglyceride levels and insulin resistance decreased high-density lipoprotein (HDL) levels (1%).
  7. Insomnia (1%).
  8. Peripheral edema (1%).
  9. Weakness (1%).
  10. Bradycardia.
  11. Chest pain.
  12. Dyspnea.

Drug Interaction

Drugs that can interact with the drug.

  1. Other Antihypertensive Medications: Combining Nebivolol with other antihypertensive medications, such as calcium channel blockers (e.g., amlodipine, verapamil), ACE inhibitors (e.g., lisinopril), or diuretics (e.g., hydrochlorothiazide).
  2. Antiarrhythmic Medications: Nebivolol may interact with certain antiarrhythmic drugs, particularly those that affect heart rhythm, such as amiodarone or quinidine.
  3. Alpha-Adrenergic Agonists: Combining Nebivolol with alpha-adrenergic agonists, such as phenylephrine or clonidine.
  4. Some NSAIDs, like ibuprofen or naproxen.
  5. CYP2D6 Inhibitors: Nebivolol is metabolized in part by the liver enzyme CYP2D6. Drugs that inhibit this enzyme, such as certain antidepressants (e.g., fluoxetine) and antipsychotics.
  6. Monoamine Oxidase Inhibitors (MAOIs): Concomitant use of Nebivolol with MAOIs, a class of antidepressants.
  7. Diabetes medications.
  8. Digoxin.
  9. Anesthetics.
  10. Epinephrine (Adrenaline).

Precautions

  1. Pregnancy: Category C.
  2. Lactation: Nebivolol, like many medications, may be excreted into breast milk, and its use during breastfeeding should be approached with caution.
55 thoughts on “Nebivolol”
  1. My brother suggested I might like this blog. He was once totally right. This publish truly made my day. You can not consider simply how a lot time I had spent for this info! Thanks!

  2. fantastic points altogether, you simply gained a brand new reader. What would you recommend in regards to your post that you made a few days ago? Any positive?

  3. Thanks for the sensible critique. Me & my neighbor were just preparing to do some research about this. We got a grab a book from our area library but I think I learned more clear from this post. I am very glad to see such wonderful info being shared freely out there.

  4. I was suggested this blog by my cousin. I’m now not certain whether or not this publish is written through him as nobody else recognize such certain approximately my problem. You are incredible! Thanks!

  5. Do you mind if I quote a couple of your posts as long as I provide credit and sources back to your webpage? My website is in the very same niche as yours and my users would certainly benefit from some of the information you present here. Please let me know if this ok with you. Thanks!

  6. Thanks for the diverse tips provided on this website. I have observed that many insurance companies offer consumers generous discount rates if they prefer to insure a couple of cars together. A significant volume of households own several automobiles these days, in particular those with older teenage kids still located at home, as well as the savings for policies can easily soon increase. So it is good to look for a great deal.

  7. One thing I have actually noticed is the fact that there are plenty of common myths regarding the financial institutions intentions whenever talking about home foreclosure. One misconception in particular is always that the bank wants your house. The financial institution wants your dollars, not your property. They want the bucks they lent you along with interest. Staying away from the bank will undoubtedly draw any foreclosed summary. Thanks for your write-up.

  8. certainly like your website however you have to test the spelling on several of your posts. A number of them are rife with spelling issues and I find it very bothersome to tell the reality on the other hand I抣l surely come again again.

  9. Great work! This is the type of information that should be shared around the net. Shame on the search engines for not positioning this post higher! Come on over and visit my website . Thanks =)

  10. hello!,I like your writing very much! share we communicate more about your article on AOL? I require a specialist on this area to solve my problem. May be that’s you! Looking forward to see you.

  11. Hello my loved one! I wish to say that this post is amazing, great written and come with almost all significant infos. I would like to look extra posts like this .

  12. I simply could not leave your website prior to suggesting that I extremely loved the usual info a person provide for your visitors? Is gonna be back incessantly to check up on new posts

  13. Thanks for your publish. My spouse and i have always observed that a majority of people are desirous to lose weight simply because wish to appear slim as well as attractive. However, they do not generally realize that there are other benefits for you to losing weight as well. Doctors claim that fat people have problems with a variety of ailments that can be instantly attributed to the excess weight. The great thing is that people who’re overweight and also suffering from a variety of diseases can help to eliminate the severity of the illnesses by way of losing weight. It is possible to see a gradual but noticeable improvement with health as soon as even a minor amount of fat loss is achieved.

  14. I simply could not depart your site prior to suggesting that I extremely enjoyed the standard information an individual supply for your visitors? Is gonna be back ceaselessly in order to investigate cross-check new posts

  15. Magnificent goods from you, man. I’ve understand your stuff previous to and you are just too wonderful. I actually like what you’ve acquired here, certainly like what you’re saying and the way in which you say it. You make it entertaining and you still care for to keep it smart. I can’t wait to read much more from you. This is actually a great website.

  16. Howdy! I’m at work surfing around your blog from my new iphone 4! Just wanted to say I love reading through your blog and look forward to all your posts! Keep up the superb work!

  17. Great article. It is rather unfortunate that over the last several years, the travel industry has had to fight terrorism, SARS, tsunamis, flu virus, swine flu, and also the first ever real global economic downturn. Through all this the industry has proven to be strong, resilient and dynamic, getting new approaches to deal with trouble. There are usually fresh troubles and the opportunity to which the sector must again adapt and behave.

  18. Howdy! I know this is kinda off topic however I’d figured I’d ask. Would you be interested in exchanging links or maybe guest authoring a blog post or vice-versa? My blog covers a lot of the same subjects as yours and I feel we could greatly benefit from each other. If you’re interested feel free to shoot me an e-mail. I look forward to hearing from you! Awesome blog by the way!

  19. These days of austerity plus relative anxiety about running into debt, lots of people balk against the idea of having a credit card in order to make acquisition of merchandise or maybe pay for a trip, preferring, instead just to rely on the tried in addition to trusted means of making repayment – raw cash. However, if you have the cash on hand to make the purchase entirely, then, paradoxically, that is the best time for them to use the cards for several factors.

  20. I will right away grab your rss feed as I can’t find your email subscription link or e-newsletter service. Do you have any? Kindly let me know in order that I could subscribe. Thanks.

  21. I mastered more new stuff on this weight-loss issue. 1 issue is that good nutrition is extremely vital when dieting. A massive reduction in junk food, sugary foods, fried foods, sugary foods, red meat, and white colored flour products could be necessary. Keeping wastes harmful bacteria, and harmful toxins may prevent aims for losing belly fat. While specified drugs briefly solve the issue, the awful side effects are usually not worth it, and they also never provide more than a short-lived solution. It’s a known fact that 95 of celebrity diets fail. Many thanks for sharing your notions on this website.

  22. I love your blog.. very nice colors & theme. Did you make this website yourself or did you hire someone to do it for you? Plz respond as I’m looking to create my own blog and would like to find out where u got this from. appreciate it

  23. Wonderful blog you have here but I was wondering if you knew of any user discussion forums that cover the same topics talked about here? I’d really like to be a part of group where I can get feedback from other experienced individuals that share the same interest. If you have any suggestions, please let me know. Cheers!

  24. Thanks for the strategies you share through your blog. In addition, several young women that become pregnant don’t even aim to get medical insurance because they worry they wouldn’t qualify. Although some states now require that insurers produce coverage in spite of the pre-existing conditions. Costs on most of these guaranteed plans are usually higher, but when taking into consideration the high cost of medical treatment it may be a new safer route to take to protect your financial potential.

  25. Thanks for discussing your ideas. A very important factor is that students have a choice between federal government student loan and a private student loan where it can be easier to choose student loan consolidation than with the federal education loan.

  26. Hello there! This post could not be written any better! Reading through this post reminds me of my good old room mate! He always kept chatting about this. I will forward this write-up to him. Pretty sure he will have a good read. Thank you for sharing!

  27. Hmm it appears like your site ate my first comment (it was super long) so I guess I’ll just sum it up what I submitted and say, I’m thoroughly enjoying your blog. I too am an aspiring blog writer but I’m still new to the whole thing. Do you have any helpful hints for first-time blog writers? I’d certainly appreciate it.

  28. Wonderful beat ! I wish to apprentice while you amend your site, how could i subscribe for a blog web site? The account helped me a acceptable deal. I had been tiny bit acquainted of this your broadcast provided bright clear idea

  29. Hello! I’m at work browsing your blog from my new iphone 3gs! Just wanted to say I love reading your blog and look forward to all your posts! Carry on the outstanding work!

Leave a Reply

Your email address will not be published. Required fields are marked *