Generic Name : Chlorpheniramine.

Trade Name     : Anallerge.

Drug Class      : Anti-histamines  (1st Generation).

Forms of The Drug

  1. Tablet: 4mg, 8mg, 12mg.
  2. Syrup: 2mg/5mL.

Mechanism of Action

Chlorpheniramine is a first-generation antihistamine with a mechanism of action similar to other drugs in its class. It is widely used for the treatment of allergic conditions such as hay fever, allergic rhinitis, and allergic conjunctivitis. The mechanism of action of chlorpheniramine involves its interaction with histamine receptors and other neurotransmitter systems. Here’s how it works:

  1. Histamine Receptor Antagonism: Chlorpheniramine acts primarily by competitively antagonizing histamine receptors, particularly the H1 receptors. Histamine is a chemical released by mast cells and basophils during allergic reactions, leading to symptoms such as itching, sneezing, runny nose, and watery eyes. By blocking the H1 receptors, chlorpheniramine prevents histamine from binding and exerting its effects, thereby alleviating allergic symptoms.
  2. Inhibition of Histamine Release: Chlorpheniramine has been shown to inhibit the release of histamine from mast cells and basophils. This further reduces the concentration of histamine available to bind to its receptors, amplifying its antiallergic effects.
  3. Anticholinergic Effects: Chlorpheniramine possesses anticholinergic properties, meaning it blocks the action of acetylcholine, a neurotransmitter in the nervous system. This action contributes to its ability to dry mucous membranes and reduce secretions, such as nasal discharge and tearing, often associated with allergic reactions.
  4. Sedative Effects: Chlorpheniramine, like many first-generation antihistamines, can penetrate the blood-brain barrier and exert sedative effects by antagonizing histamine receptors in the central nervous system. This sedation can be beneficial for individuals experiencing allergic symptoms, particularly those associated with insomnia or nighttime allergies. However, it can also lead to drowsiness and impair psychomotor function, which may limit its use in certain situations.
  5. Other Neurotransmitter Effects: Chlorpheniramine may interact with other neurotransmitter systems in the brain, such as serotonin and dopamine receptors, although the significance of these interactions in its therapeutic effects is not fully understood.

Indications

  1. Allergic Rhinitis.
  2. Allergic Conjunctivitis.
  3. Urticaria (Hives).
  4. Pruritus (Itching).
  5. Allergic Dermatological Conditions: such as atopic dermatitis or contact dermatitis, including itching, redness, and inflammation.
  6. Insect Bites and Stings.
  7. Angioedema.
  8. Motion Sickness.

Contraindications

  1. Hypersensitivity.
  2. Narrow-Angle Glaucoma.
  3. Severe Lower Respiratory Tract Symptoms: such as asthma exacerbations, acute bronchitis, or chronic obstructive pulmonary disease (COPD).
  4. Acute Asthma Attack.
  5. Newborns and Premature Infants.
  6. Breastfeeding.
  7. Use with MAOIs.
  8. Bladder Neck Obstruction.

Side Effects

  1. CNS depression.
  2. Drowsiness.
  3. Sedation ranging from mild drowsiness to deep sleep (most frequent).
  4. Dizziness.
  5. Lassitude.
  6. Disturbed coordination.
  7. Muscular weakness.
  8. Restlessness, insomnia, tremors, euphoria, nervousness, delirium, palpitation, seizures is less common.
  9. Epigastric distress.
  10. Anorexia.
  11. Nausea.
  12. Vomiting.
  13. Diarrhea.
  14. Constipation.
  15. Cholestasis, hepatitis, hepatic failure, hepatic function abnormality, jaundice is rare.
  16. Tachycardia, palpitation ECG changes (eg, widened QRS).
  17. Arrhythmias (eg, extrasystole, heart block).
  18. Hypotension.
  19. Hypertension.
  20. Dizziness, sedation, and hypotension may occur in geriatric patients.

Drug Interaction

  1. Central Nervous System Depressants such as benzodiazepines, opioids, barbiturates, and alcohol.
  2. Anticholinergic effects, such as tricyclic antidepressants, antipsychotics, certain antispasmodics, and certain medications for overactive bladder.
  3. Monoamine Oxidase Inhibitors (MAOIs).
  4. Selective Serotonin Reuptake Inhibitors (SSRIs) and Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs).
  5. CNS stimulants, such as amphetamines or methylphenidate.
  6. Antihypertensive Medications: such as beta-blockers or alpha-blockers.
  7. Anticholinesterase Inhibitors.
  8. Urinary Alkalizers, such as sodium bicarbonate or potassium citrate.

Precautions

  1. Pregnancy: Category B.
  2. Lactation: Chlorpheniramine is excreted into breast milk, and its use during lactation is generally considered compatible with breastfeeding.

18 thoughts on “Chlorpheniramine (Anallerge)”
  1. Pretty section of content. I just stumbled upon your weblog and in accession capital to assert that I acquire actually enjoyed account your blog posts. Any way I抣l be subscribing to your feeds and even I achievement you access consistently fast.

  2. Hello there, I discovered your site by the use of Google at the same time as searching for a related topic, your web site got here up, it looks great. I have bookmarked it in my google bookmarks.

  3. I’m extremely impressed with your writing skills as well as with the layout on your weblog. Is this a paid theme or did you modify it yourself? Either way keep up the excellent quality writing, it is rare to see a great blog like this one today..

  4. Thank you for this article. I’d also like to state that it can always be hard when you find yourself in school and just starting out to initiate a long credit ranking. There are many individuals who are just trying to live and have a long or good credit history are often a difficult matter to have.

  5. Oh my goodness! a tremendous article dude. Thanks However I’m experiencing situation with ur rss . Don抰 know why Unable to subscribe to it. Is there anybody getting an identical rss problem? Anybody who knows kindly respond. Thnkx

  6. Wonderful goods from you, man. I have understand your stuff previous to and you are just too magnificent. I really like what you have acquired here, really like what you’re stating and the way in which you say it. You make it enjoyable and you still care for to keep it sensible. I cant wait to read much more from you. This is actually a tremendous site.

  7. whoah this blog is wonderful i love reading your articles. Keep up the good work! You know, many people are looking around for this information, you can help them greatly.

  8. Hi! I could have sworn I’ve been to this website before but after reading through some of the post I realized it’s new to me. Anyhow, I’m definitely happy I found it and I’ll be book-marking and checking back often!

  9. I do not even know how I ended up here, but I thought this post was great. I don’t know who you are but certainly you are going to a famous blogger if you are not already 😉 Cheers!

  10. In these days of austerity in addition to relative panic about getting debt, many individuals balk about the idea of using a credit card to make acquisition of merchandise or maybe pay for a vacation, preferring, instead to rely on a tried plus trusted method of making settlement – cash. However, if you possess cash on hand to make the purchase fully, then, paradoxically, this is the best time for them to use the cards for several good reasons.

  11. Thanks , I’ve recently been searching for information approximately this topic for ages and yours is the greatest I’ve discovered till now. But, what concerning the conclusion? Are you positive concerning the source?

  12. I’m extremely inspired with your writing talents and also with the structure on your weblog. Is this a paid topic or did you modify it yourself? Either way keep up the nice quality writing, it is rare to look a nice blog like this one nowadays..

  13. Thanks for all your effort on this blog. Kim delights in working on investigations and it’s really simple to grasp why. All of us know all about the dynamic medium you present reliable ideas on your blog and even boost contribution from some other people on this article so our princess is without question studying a lot of things. Enjoy the remaining portion of the year. You’re the one performing a great job.

  14. Thanks a lot for providing individuals with a very spectacular chance to discover important secrets from this blog. It can be so nice and full of fun for me personally and my office colleagues to search the blog minimum thrice every week to find out the new secrets you will have. Of course, I’m so certainly happy with the striking opinions served by you. Selected 2 points in this post are in truth the very best we have had.

  15. Nice blog here! Also your web site quite a bit up fast! What web host are you using? Can I get your affiliate hyperlink in your host? I want my website loaded up as fast as yours lol

  16. Nice post. I was checking continuously this blog and I’m impressed! Very helpful information specifically the last part 🙂 I care for such information much. I was seeking this particular info for a long time. Thank you and best of luck.

  17. It’s appropriate time to make a few plans for the future and it is time to be happy. I have read this submit and if I may just I want to suggest you some fascinating things or tips. Perhaps you could write subsequent articles relating to this article. I wish to learn even more issues about it!

Leave a Reply

Your email address will not be published. Required fields are marked *